Initial responses to questionnaires used to assess participants' understanding of informed consent for malaria vaccine trials conducted in the United States and Mali were tallied. Total scores were analyzed by age, sex, literacy (if known), and location. Ninety-two percent (92%) of answers by United States participants and 85% of answers by Malian participants were correct. Questions more likely to be answered incorrectly in Mali related to risk, and to the type of vaccine. For adult participants, independent predictors of (...) higher scores were younger age and female sex in the United States, and male sex in Mali. Scores in the United States were higher than in Mali (P = 0.005). Despite this difference participants at both sites were well informed overall. Although interpretation must be qualified because questionnaires were not intended as research tools and were not standardized among sites, these results do not support concerns about systematic low understanding among research participants in developing versus developed countries. (shrink)

In a given polity, interactions between the Governed and the Governing Strata are symbiotic. The Governed desire, and indeed need, infrastructure services organized. If such basic foundations are not provided, the economic activity so deeply cherished by both groups cannot be realized. The Governing Strata cannot function without the Governed. After all, without the Governed, there will not be a polity; hence nothing to govern. Regardless of the politico-economic system in effect, this co-dependence is inevitable, inescapable, indenturing both groups to (...) each other. This is the case, regardless of the designation, functions, or the style of the governance system. It matters not if the designation or philosophy of the said governance is a variation of pluralism or authoritarianism by a minority. (shrink)

An outline of the life of Heraclides and his fragmentary writings (on the theory of matter, astronomy, ethical and religious topics) is followed by an attempt to reconstruct his thought. He emerges as not so much a profound thinker as a many-sided writer of considerable literary gifts and occasional flashes of brilliance.

It is proposed in this paper to develop a method by which the most general problem of the algebra of propositions is solved. This problem is to construct all propositions whose truth is independent of the form of the variables. As might be expected this method will enable us to determine without the use of matrices the consistency and independence of propositions, except in the case of those fundamental properties, which taken together define consistency itself. In the discussion which follows (...) no limitations are placed on the meaning of the terms and the word proposition is used simply in the sense of a variable. If we were to say, for example, that our variables must be restricted to zero or one values, we would be introducing a limitation which would reduce the generality of our science. A logic may be false in the sense that its postulates lead to contradictory theorems, or it may be false in the sense that it lacks generality, and the situation is not saved by calling it a two-valued, or a three-valued logic, or a logic of “propositions,” or by designating it by some other euphuism. (shrink)

Gotthold Ephraim Lessing, thinker, dramatist and controversialist of many-sided interests, is the most representative figure of the German Enlightenment. His defence of Spinoza, who had traditionally been condemned as an atheist, provoked a major controversy in philosophy, and his publication of H. S. Reimarus' radical assault on Christianity led to fundamental changes in Protestant theology. This volume presents the most comprehensive collection to date in English of Lessing's philosophical and theological writings, several of which are here translated for the first (...) time. They are edited and translated by H. B. Nisbet, who also provides an introduction that sets them in their historical and philosophical contexts. (shrink)

The so-called fourth book of Aristotle's Meteorologica is not about meteorological phenomena at all. It describes the formation out of the four elements of ‘homoeomerous’ substances, by which are meant minerals such as stones and metals, and organic substances like flesh, skin, and hair, and the changes they can undergo under the influence of heat, cold, and moisture. Most commentators, ancient and modern, have seen that it has very little to do with the first three books of the Meteorologica to (...) which it is attached, and Alexander suggested that it should be placed after the second book de Generation et Corruptione. (shrink)